Over the last couple of years, the news has been filled with groundbreaking research on the potential benefits of Psilocybin Mushrooms or Magic Mushrooms. However, the lack of progress toward legalizing or decriminalizing their use has made it hard to remain optimistic. But fear not; a team of Yale University researchers has arrived. Their latest discoveries were recently published in Neuron in July 2021, offering new hope for the future of these mysterious fungi.

The potential for psilocybin to aid recovery from depression has been explored and researched for decades. Yet, using psychoactive drugs to treat mental illness remains a contentious topic among scientific communities. The lack of understanding regarding how psilocybin interacts with the depressed brain is a critical factor in these debates.

Fortunately, the Yale research team, led by Alex Kwan, has shed some light on this issue. Kwan, an associate professor of psychiatry and neuroscience, conducted a study on the effects of psilocybin in the brains of mice.

The results showed that a single dose of psilocybin led to an immediate and long-lasting increase in the connections between neurons in the brain. Kwan notes, “We not only saw a 10% increase in the number of neuronal connections, but also they were about 10% larger on average, so the connections were stronger as well.”

Given that individuals with depression or chronic stress often have lower levels of neural connectivity, repairing these connections in the brain may aid in healing. From a neurological perspective, psilocybin could present a significant opportunity to treat depression.

Under a microscope, neurons reveal a distinct feature known as the dendritic spine. This protrusion on the neuron is responsible for receiving synaptic input, allowing the neuron to “fire.” Interestingly, when the dendritic spines of mice administered with psilocybin were examined, Kwan and his team observed several changes, most notably an improvement in stress-related behavioral deficits.


The Benefits of Psilocybin Mushrooms

The benefits of psilocybin mushrooms extend beyond stress reduction, however. Other reported effects include enhanced mood, emotional stability, mindfulness, presence, openness, and self-forgiveness. Additionally, psilocybin has been linked to increased empathy, sociability, and a greater sense of connection with others. These effects make psilocybin a promising candidate for treating depression, anxiety, ADD/ADHD, PTSD, and more.

Concluding the Matter

To summarize our discussion, we have explored the numerous benefits of psilocybin in treating mental illnesses like depression. Alex Kwan and his team from Yale published a groundbreaking study on the molecular changes in neurons following psilocybin administration. This study offers hope for using magic mushrooms as a legitimate alternative treatment.

African Transkei and Golden Teachers are among the best if you’re interested in mushroom strains. Microdosing, taking a small portion of the drug to feel its psychological effects without undesirable effects, is often the best approach for anxiety, depression, or mental illnesses.

One of the notable findings from the study is that psilocybin increased the spine density and size in frontal cortical pyramidal cells, leading to enhanced excitatory neurotransmission even a month after treatment. This enduring effect is promising and exciting, and it shows the potential of psilocybin to shape and rewire our brains.

Microdosing mushrooms has numerous benefits, including the production of a specialized protein called BDNF, which enables new neurological connections that bring various benefits, according to some studies. While full-dose therapies have perception-distorting properties, microdosing may offer complementary clinical benefits using lower-risk, non-hallucinogenic doses.


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